Hitoshi Inada

IntelliProfiler 2.0 is an R pipeline for analyzing RFID tracking data from group-housed mice, capturing circadian and sex-dependent behavioral patterns with improved reproducibility.

The paper predicts post-pubertal social behavior variability in a mouse model of paternal 15q11-13 duplication using neonatal social communication and gene expression data.

IntelliProfiler analyzes multi-animal behavior in home cages using RFID data to quantify locomotion and social interactions, revealing sex, age, and paternal-aging effects on social behavior.

Advanced paternal age affects vocal development in early postnatal mice, with more pups showing atypical developmental trajectories.

The paper identifies 124 FMRP target genes in murine embryonic neocortex, finds 48 overlapping with autism-related genes, and shows expression changes in four genes in Fmr1-KO mice.

The paper shows that paternal age affects offspring behavior through epigenetic changes in sperm DNA methylation, leading to altered gene expression and neuronal abnormalities.

This study shows that increasing KCC2 in mice reduces seizure-like activity and prevents status epilepticus, suggesting KCC2 targeting could help treat excitation-inhibition imbalances.