Hiroaki Wake

This study shows that disrupting developmental myelination in the medial prefrontal cortex impairs adult social behavior and PV interneuron function in mice, with parallels in human schizophrenia.

This paper identifies a preoptic circuit involving Crh-expressing neurons that initiates rewarming from torpor in mice and shows similar activation in hibernators.

This study identifies a role for subarachnoid macrophages in amyloid-beta clearance and vascular dysfunction in Alzheimer's disease using mouse models and intravital imaging.

This study identifies dysregulated synaptic gene expression in oligodendrocytes of SBMA mice, highlighting early cell-to-cell communication changes as a potential therapeutic target.

This paper introduces an unsupervised deep learning method for deblurring, super-resolution, and segmentation of two-photon microscopy images, achieving better performance than conventional methods.

This study shows that border-associated macrophages infiltrate the embryonic cerebral wall and differentiate into microglia through a specific developmental pathway.

This study shows that increasing KCC2 in mice reduces seizure-like activity and prevents status epilepticus, suggesting KCC2 targeting could help treat excitation-inhibition imbalances.