RNF213 M1-ubiquitinates damaged mitochondria to activate pro-inflammatory NF-κB signaling
Rosalie Heilig, Hannah Glover, Charlotte E. L. Mellor, Catherine Cloix, Michael J. McIlwraith, Lyndsey Flanagan, Nikki R. Paul, Peter Thomason, Bodhayan Prasad, Asma Ahmed, Hugo Dupuis, Destiny Dalseno, Leah Smith, James Hamilton, Ella Hall-Younger, , Stephen WG Tait
This study identifies RNF213 as an E3 ligase that catalyzes M1-linked ubiquitination of damaged mitochondria, activating pro-inflammatory NF-κB signaling through NEMO recruitment.
bioRxiv · Sep 22, 2026 · PreprintCell Biology