Nikki R. Paul

This study identifies RNF213 as an E3 ligase that catalyzes M1-linked ubiquitination of damaged mitochondria, activating pro-inflammatory NF-κB signaling through NEMO recruitment.

CYCLOPS provides an open-source platform for cyclic multiplex imaging and single-cell phenotyping using standard microscopy infrastructure, enabling reproducible and accessible spatial proteomics.

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.