Integrative Proximal-Ubiquitomics Profiling for Deubiquitinase and E3 Ligase Substrate Discovery Applied to USP30
Andreas Damianou, Hannah B. L. Jones, Athina Grigoriou, Iolanda Vendrell, Simon A. Davis, Benedikt Mathias Kessler
The paper identifies direct substrates of the DUB USP30 using a proximal-ubiquitome workflow combining APEX2 and ubiquitination enrichment.
bioRxiv · Oct 7, 2024 · PreprintMolecular Biology