Iolanda Vendrell

This study shows that the N-terminal truncation of USP18 generates a short isoform (SF) with distinct functions in muscle differentiation compared to the long isoform (LF).

This study uses time-resolved proteomics to analyze host protein changes during early HBV infection, revealing coordinated proteome alterations and specific complement pathway dynamics.

This paper develops a spatial pharmacology workflow using LCM-LC-PRM to profile MMAE distribution in tumour and healthy tissues, revealing heterogeneous and time-dependent accumulation patterns.

This study shows that senescent tenocytes contribute to age-related tendon degeneration and that dihydroresveratrol can partially restore matrix homeostasis.

This study identifies a stabilized PABPN1 variant, trPAB, that reduces aggregation and restores function in OPMD and bladder cancer models, supporting its potential as a gene therapy.

The paper investigates Menin's role in enhancer-promoter interactions in MLL-rearranged and NPM1c leukemia models, finding context-dependent effects on transcriptional regulation and enhancer function.

This study identifies lithium's effects on synaptic phosphoproteome in mouse synaptoneurosomes, revealing multi-kinase network changes linked to bipolar disorder.

This study shows human iPSC-derived microglia uptake and process tau fibrils, leading to secretion in extracellular vesicles that can seed tau aggregation in neurons.

The paper identifies ThrEDs, a novel type of extracellular particle that accelerates wound healing and reduces fibrotic responses in patient-derived myofibroblasts.

This paper develops cyclin A/B macrocyclic inhibitors that induce apoptosis in cancers with high E2F activity by blocking RxL-mediated interactions, showing efficacy in SCLC models.

This paper introduces a high-throughput activity proteomics pipeline for discovering deubiquitinase inhibitors, identifying potent and selective inhibitors with minimal optimization.

This study identifies FBXO42 as a regulator of PP4 phosphatase activity, showing its role in controlling cellular processes through ubiquitination of PP4.

This paper introduces Huib32, a selective USP32 inhibitor, and two activity-based probes that modulate endosomal processes and provide tools for studying USP32 in cancer and neurodegenerative diseases.

This study shows bisphosphonates reduce senescence markers and alter proteomes in multiple cell types, suggesting anti-ageing effects beyond bone health.

This study shows that the EMC3 subunit is critical for lipid droplet homeostasis in mice and Drosophila, with loss of EMC3 causing triglyceride storage defects and reduced FITM2 levels.

This study shows USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms, enhancing mitophagy and mitochondrial efficiency in neurons.

This study investigates the structural dynamics of USP30 inhibition by a covalent inhibitor, revealing its binding mechanism and selectivity advantages over non-covalent inhibitors.

The paper identifies direct substrates of the DUB USP30 using a proximal-ubiquitome workflow combining APEX2 and ubiquitination enrichment.

The paper identifies AP2S1 variants linked to neurodevelopmental disorders by showing they impair clathrin-mediated endocytosis and disrupt protein interactions.

The paper identifies synthetic lethality between Chk1 inhibition and cyclin F loss, revealing Cyclin F's role in preventing DNA replication stress via E2F1 degradation.