Author
University of OxfordORCID 0000-0002-7834-0625Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Hannah B. L. Jones, Simeon D. Draganov, Sofia Schönbauer Huamán…·Adán Pinto-Fernández
This paper introduces a high-throughput activity proteomics pipeline for discovering deubiquitinase inhibitors, identifying potent and selective inhibitors with minimal optimization.
Matthew G Williamson, Rachel Heon‐Roberts, Sarah N. J. Franks…·Brent James Ryan
This study shows USP30 inhibition improves mitochondrial health through both PINK1-dependent and independent mechanisms, enhancing mitophagy and mitochondrial efficiency in neurons.
Darragh Patrick O'Brien, Hannah B. L. Jones, Yuqi Shi…·Benedikt Mathias Kessler
This study investigates the structural dynamics of USP30 inhibition by a covalent inhibitor, revealing its binding mechanism and selectivity advantages over non-covalent inhibitors.
Andreas Damianou, Hannah B. L. Jones, Athina Grigoriou…·Benedikt Mathias Kessler
The paper identifies direct substrates of the DUB USP30 using a proximal-ubiquitome workflow combining APEX2 and ubiquitination enrichment.