New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy
Yang Yang, Holly J. Garringer, Yang Shi, Sofia Lövestam, Xianjun Zhang, Abhay Kotecha, Mehtap Bacioglu, Atsuo Koto, Masaki Takao, Maria Grazia Spillantini, Bernardino Francesco Ghetti, Rubén Vidal, Alexey G. Murzin, Sjors H. W. Scheres, Michel Goedert
The paper identifies a SNCA mutation causing juvenile-onset synucleinopathy and describes the structural features of α-synuclein filaments associated with the disease.
bioRxiv · Nov 23, 2022 · PreprintNeuroscience