Rubén Vidal

TREM2 deficiency causes region-specific brain effects in a mouse model of cerebral amyloid angiopathy

This study shows that TREM2 deficiency causes region-specific changes in vascular amyloid and tau pathology in a mouse model of cerebral amyloid angiopathy.

Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease

This study uses single-nucleus RNA sequencing to show that tau ablation alters brain cell programs in health and restores function in vascular amyloid disease.

Phosphorylation at serine 214 correlates with tau seeding activity in an age-dependent manner in two mouse models for tauopathies and is required for tau transsynaptic propagation.

The paper investigates the correlation between phosphorylation at serine 214 and tau seeding activity in mouse models, showing its role in tau propagation.

Novel tau filament folds in individuals with MAPT mutations P301L and P301T

The paper reports cryo-EM structures of tau filaments from individuals with P301L and P301T MAPT mutations, revealing distinct filament folds associated with FTDP-17.

Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C

This study identifies heteromeric amyloid filaments composed of ANXA11 and TDP-43 in FTLD-TDP Type C using cryo-EM, revealing a new pathological mechanism.

Cross-β helical filaments of Tau and TMEM106B in Gray and White Matter of Multiple System Tauopathy with presenile Dementia

The paper determines that tau and TMEM106B filaments from gray and white matter in MSTD have identical folds.

New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy

The paper identifies a SNCA mutation causing juvenile-onset synucleinopathy and describes the structural features of α-synuclein filaments associated with the disease.

Cryo-EM structures of α-synuclein filaments from Parkinson's disease and dementia with Lewy bodies

The paper reports cryo-EM structures of α-synuclein filaments from Parkinson's disease, PD dementia, and dementia with Lewy bodies, showing they are composed of a single protofilament distinct from those in multiple system atrophy.

Age-dependent formation of TMEM106B amyloid filaments in human brain

This study identifies age-dependent formation of TMEM106B amyloid filaments in human brains using cryo-EM, showing they appear in older individuals but not younger ones.

Cryo-EM Structures of Amyloid-β 42 Filaments from Human Brain

Cryo-EM shows brain-derived Aβ42 filaments adopt two related S-shaped protofilament folds: Type I dominates sporadic Alzheimer's, Type II familial Alzheimer's, other disorders and App^NL-F knock-in mice.

Structure-based Classification of Tauopathies

Cryo-EM structures sort four-repeat tauopathies into three-layered (PSP, GGT, LNT) and four-layered (CBD, AGD, ARTAG, MAPT intron 10 mutations) tau folds, grounding a hierarchical structure-based classification.

Novel tau filament fold in corticobasal degeneration, a four-repeat tauopathy

This paper reports the structure of tau filaments in corticobasal degeneration using cryo-EM, revealing a novel four-layered fold distinct from other tauopathies.

Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold

The paper determines the structure of tau filaments in Alzheimer's disease cases and finds they adopt a common fold across individuals.