Induced alanine auxotrophy as a therapeutic strategy against Mycobacterium tuberculosis
Menna-Allah W. Shalaby, Nagabhushana C. Beeralingappa, Annadka Shrinidhi, Gaëlle Guiewi Makafe, Evan Nece, Aditya Patwardhan, Timothy C. Low-Beer, Atsuo Kuki, Felix B. Sheinerman, Brian C. Weinrick, Daniel Patrick Flaherty, Michaelle Chojnacki
The paper identifies TI-374 and TI-801 as inhibitors of Mycobacterium tuberculosis's AlaA enzyme, showing their efficacy against intracellular Mtb and supporting AlaA as a therapeutic target.
bioRxiv · Jun 16, 2026 · PreprintPharmacology & Toxicology