Author
Purdue University West LafayetteORCID 0000-0002-8305-0606Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Rishi S. Patel, Nipuni M. Pannala, Chih-Hsuan Lai…·Chittaranjan Das
This study identifies substrate biasing in UCHL5 proteoforms, showing N-terminal ubiquitination activates the enzyme toward monoubiquitin substrates and regulates debranching activity.
Menna-Allah W. Shalaby, Nagabhushana C. Beeralingappa, Annadka Shrinidhi…·Michaelle Chojnacki
The paper identifies TI-374 and TI-801 as inhibitors of Mycobacterium tuberculosis's AlaA enzyme, showing their efficacy against intracellular Mtb and supporting AlaA as a therapeutic target.
Nagabhushana C. Beeralingappa, Mengyao Lu, Rishi S. Patel…·Daniel Patrick Flaherty
This study identifies and optimizes a chloroacetamide scaffold as a covalent inhibitor for UCHL3, supported by structural and biochemical validation.