Microglia and astrocytes differentially endocytose exosomes facilitating alpha-Synuclein endolysosomal sorting
Marina Pantazopoulou, Anastasia Alexaki, Agaristi Lamprokostopoulou, Athanasios Delis, Audrey Coens, Ronald Melki, Stamatis N. Pagakis, Leonidas Stefanis, Kostas Vekrellis
This study investigates how microglia and astrocytes internalize and sort brain-derived exosomes, showing differential uptake efficiency and endosomal trafficking of exosome-associated alpha-synuclein.
bioRxiv · Aug 5, 2022 · PreprintNeuroscience