Wouter Peelaerts

The paper evaluates three Syn aggregation inhibitors in a cellular model of a-synuclein aggregation using single-cell RNA sequencing to identify transcriptional changes and potential druggable pathways.

This paper develops CNNs for automated brain-wide histopathological analysis in mouse synucleinopathy models, enabling rapid, unbiased detection of neurodegeneration markers.

This study shows that T cells reduce phosphorylated α-synuclein pathology in a mouse model of α-synucleinopathy.

This study shows that different a-Synuclein strains influence MSA progression through central and peripheral immune mechanisms, with strain-dependent effects on neurodegeneration and glial responses.

The paper tests if inhibiting the mitochondrial pyruvate carrier reduces synucleinopathy in PD models but finds no effect on Syn aggregation or neurodegeneration.