Veerle Baekelandt

The paper evaluates three Syn aggregation inhibitors in a cellular model of a-synuclein aggregation using single-cell RNA sequencing to identify transcriptional changes and potential druggable pathways.

This paper develops CNNs for automated brain-wide histopathological analysis in mouse synucleinopathy models, enabling rapid, unbiased detection of neurodegeneration markers.

This study shows that ATP10B loss causes dopaminergic neuron death and Parkinsonian symptoms in rats and human stem cell models.

This study identifies PAK6 as a positive regulator of neuronal autophagy through TFEB nuclear translocation, with implications for neurodegenerative disease treatment.

The paper functionally characterizes ATP13A2 variants linked to neurodegenerative disorders, finding that only the homozygous NCL variant causes complete loss-of-function, while others show subtle defects.

This study shows that RIT2 inhibits LRRK2 kinase activity, reduces aSyn inclusions, and protects neurons in Parkinson's disease models.

This study shows that different a-Synuclein strains influence MSA progression through central and peripheral immune mechanisms, with strain-dependent effects on neurodegeneration and glial responses.