Audrey Durand

Loss of resistance to punishment of cocaine use after prior experience

The paper shows that resistance to punishment in cocaine use is not stable, as rats become less resistant after retesting and suppress intake with lower punishment intensity.

Pharmacokinetics trumps pharmacodynamics during cocaine choice: a reconciliation with the dopamine hypothesis of addiction

This study reconciles the dopamine hypothesis of addiction with cocaine choice behavior by showing pharmacokinetics, not pharmacodynamics, determines reward preference in rats.

Persistent vulnerability to relapse despite complete extinction of cocaine craving

This study shows that complete extinction of cocaine priming in rats does not prevent relapse, suggesting the presence of extinction-resistant behavior that contributes to relapse vulnerability.

An integrated homeostatic reinforcement learning theory of motivation explains the transition to cocaine addiction

This paper develops a computational theory integrating homeostatic regulation and reinforcement learning to explain cocaine addiction, showing how chronic use leads to increased drug-seeking behavior and relapse.