Genetic accessibility, not superior fitness, determines which anti-HBs antibody escape variants are selected in patients
Yingpu Yu, Eleftherios Michailidis, Leon Louis Seifert, Mengyin Zhang, Chenhui Zou, Catherine A. Freije, Georgios Dangas, Antonis Athanasiadis, Andreas S. Puschnik, Audrey Hanson, Evelyn Rocha, Yi-Pei Chen, 洪徐鹏, Corrine Quirk, Yichen Zhou, , Ype P. de Jong
This study identifies that genetic accessibility, not superior fitness, determines the selection of anti-HBs antibody escape variants in patients using in vivo screening.
bioRxiv · Oct 8, 2026 · PreprintMicrobiology