Eleftherios Michailidis

A novel proviral mechanism for the ISG, Shiftless, during human coronavirus infection

This study reveals that the ISG Shiftless (SHFL) has both antiviral and proviral functions during coronavirus infection, enhancing susceptibility while modulating IFN signaling.

Genetic accessibility, not superior fitness, determines which anti-HBs antibody escape variants are selected in patients

This study identifies that genetic accessibility, not superior fitness, determines the selection of anti-HBs antibody escape variants in patients using in vivo screening.

The HBV basal core promoter mutation confers a replicative advantage and transcriptionally reprograms hepatocytes toward HCC subtypes

This study shows that HBV BCP mutations enhance viral replication and alter hepatocyte transcription, linking to specific HCC subtypes.

A CRISPR-Cas9 platform for primary human hepatocytes enables arrayed screening and in vivo validation of HBV host factors

The paper develops CRISPR-Cas9 delivery methods for primary human hepatocytes to enable efficient gene editing and screening of HBV host factors.

Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factors

The paper identifies HBV host factors using CRISPR screens and human liver chimeric mice, finding that EXOC1 is antiviral and ZCCHC14 is proviral.

Structural and Mechanistic Basis of F227C-Mediated Hypersusceptibility to Islatravir in HIV-1 Reverse Transcriptase

The paper investigates how the F227C mutation in HIV-1 reverse transcriptase increases susceptibility to islatravir, revealing structural and mechanistic insights into this collateral sensitivity.

Unraveling the Mechanism of HIV-1 Hypersusceptibility to Tenofovir Imparted by Islatravir Resistance Mutations

The paper investigates how HIV-1 resistance mutations enhance susceptibility to tenofovir by analyzing structural and biochemical changes in reverse transcriptase.

A short HBV RNA region induces RNR-R2 expression in non-cycling cells and in primary human hepatocytes

The paper identifies a 125-base RNA region in HBV transcripts that induces RNR-R2 expression in non-cycling cells and primary human hepatocytes without requiring HBx protein.