VirB, a key transcriptional regulator of Shigella virulence, requires a CTP ligand for its regulatory activities
Taylor M. Gerson, Audrey M. Ott, Monika M. A. Karney, Jillian N. Socea, Daren R. Ginete, Lakshminarayan M. Iyer, Lakshminarayanan Aravind, Ronald K. Gary, Helen J. Wing
This paper identifies CTP as a ligand for the Shigella virulence regulator VirB, showing that CTP binding is essential for its regulatory functions and virulence phenotypes.
mBio · Sep 20, 2023Peer-reviewedMicrobiology