Lakshminarayanan Aravind

The paper identifies ParA-like NTPases as key components in prokaryotic immunity, revealing diverse strategies to combat selfish genetic elements.

This paper characterizes SRLase1, an RNase toxin that cleaves the sarcin-ricin loop of 23S rRNA by repurposing EF-Tu, revealing a new mechanism of ribosome inhibition.

This study identifies a lipid cue that drives the subcellular localization of a bacterial transmembrane protein, ShfA, by binding to undecaprenyl phosphate.

40S subunit binding to a previously unrecognised RRM in LARP1 activates its TOP-binding HEAT repeats, licensing repression of ribosomal protein mRNA translation in human cells.

The paper classifies BECR ribonuclease proteins across domains of life using structural and genomic analysis, revealing new families and refining existing classifications.

The paper identifies Pucsar, a bacterial antiphage system that uses 3,5-cGMP generated by a cyclase to activate TIR effectors through a stepwise filament assembly process.

This study identifies EOLA1 as a deacetylase that recycles N4-acetylcytidine (acC) in nucleotide salvage, revealing a pathway for modified nucleotide recycling relevant to therapeutic RNA design.

The paper identifies a novel family of lipid-targeting antibacterial toxins from Salmonella using in-silico analysis of genomes and biochemical characterization.

The paper identifies a methylome-derived m6-dAMP trigger that forms an immune filament in E. coli to deplete dNTPs and abort phage infection.

The paper identifies a novel antiphage system, Panoptes, that uses a minimal CRISPR polymerase to produce cyclic nucleotides and detects phage anti-defense proteins through effector binding and nucleotide depletion.

The paper identifies the Lipocone superfamily as a unifying theme in lipid metabolism, inter-organismal conflicts, and immunity across species.

The paper shows that male gametophyte development in Arabidopsis is controlled by the sporophyte through SHUKR, a gene that represses ubiquitination genes involved in post-meiotic gametogenesis.

This study characterizes TkNat10, an RNA acetyltransferase from T. kodakarensis, showing its role in thermotolerance and its ability to modify RNA substrates with specific sequence preferences.

The paper shows that HrpA, an RNA helicase in E. coli, rescues stalled ribosomes by splitting collided ribosomes into subunits using ATP hydrolysis.

The paper identifies CoaX, a pseudokinase, and pantothenate as regulators of proteasomal degradation of the pantothenate synthesis enzyme PanB in M. tuberculosis.

The paper identifies an ER pathway that regulates N-glycosylation by modulating OST-A activity, impacting cell-surface signaling and tissue development.

This study shows that bacterial differentiation through altruistic feeding and cell-cell signaling increases phenotypic heterogeneity, enhancing population resilience to environmental changes.

The paper identifies novel partners and evolutionary history of phage shock protein (PSP) systems across bacteria, showing their presence in LUCA and diversification into new functional contexts.

This study shows that MutS2 in B. subtilis splits stalled ribosomes into subunits without cleaving mRNA, differing from the E. coli SmrB mechanism.

This paper identifies CTP as a ligand for the Shigella virulence regulator VirB, showing that CTP binding is essential for its regulatory functions and virulence phenotypes.

The paper investigates how Pirh2 and CRL2-KLHDC10 E3 ligases recognize Ala-tails, showing conserved binding sites and convergent evolution of their recognition mechanisms.

The paper shows that gene-teratogen interactions affect birth defect penetrance by altering Hedgehog signaling through the MMM complex and SMO degradation.

The paper identifies SmrB as a factor that cleaves mRNAs upstream of stalled ribosomes in bacteria, promoting ribosome rescue through ribosome collisions.

This study identifies a ubiquitin-based genetic mechanism linking Megf8 and Mgrn1 mutations to congenital heart defects and heterotaxy through altered Hedgehog signaling.

The paper identifies NONU-1 as an endoribonuclease essential for translation surveillance pathways and shows its conservation across species.

The paper investigates the evolution of the calcium-dependent system in eukaryotes, identifying its origins and key innovations across species.

The paper identifies PCIF1 as the m6Am methyltransferase and develops a method to accurately map m6Am sites, revealing its role in mRNA stability.

The paper identifies the bacterial origin of DNA repair and kinetoplast DNA components in eukaryotes through computational analysis of protein domains.

The paper traces the evolutionary origins of Chromo-like domains and Cren7/Sul7 proteins, showing they arose from different ancestors and did not share a common evolutionary path.

This study investigates the evolutionary origin and functional roles of the transcription factor zelda in short-germ insects, revealing its involvement in MZT, posterior segmentation, and pluripotency maintenance.