Lakshminarayan M. Iyer

Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling

This paper identifies a novel non-enzymatic role for BVRA in modulating Nrf2 signaling, revealing its importance in neuroprotection and potential as a therapeutic target for neurodegenerative diseases.

A sequence-specific RNA acetylation catalyst

This study characterizes TkNat10, an RNA acetyltransferase from T. kodakarensis, showing its role in thermotolerance and its ability to modify RNA substrates with specific sequence preferences.

Identification of a proteolysis regulator for an essential enzyme in Mycobacterium tuberculosis

The paper identifies CoaX, a pseudokinase, and pantothenate as regulators of proteasomal degradation of the pantothenate synthesis enzyme PanB in M. tuberculosis.

VirB, a key transcriptional regulator of Shigella virulence, requires a CTP ligand for its regulatory activities

This paper identifies CTP as a ligand for the Shigella virulence regulator VirB, showing that CTP binding is essential for its regulatory functions and virulence phenotypes.

Functional innovation in the evolution of the calcium-dependent system of the eukaryotic endoplasmic reticulum

The paper investigates the evolution of the calcium-dependent system in eukaryotes, identifying its origins and key innovations across species.

The unexpected provenance of components in eukaryotic nucleotide-excision-repair and kinetoplast DNA-dynamics from bacterial mobile elements

The paper identifies the bacterial origin of DNA repair and kinetoplast DNA components in eukaryotes through computational analysis of protein domains.

A tangled tale of convergence and divergence: archaeal chromosomal proteins and Chromo-like domains in bacteria and eukaryotes

The paper traces the evolutionary origins of Chromo-like domains and Cren7/Sul7 proteins, showing they arose from different ancestors and did not share a common evolutionary path.

The roles of Conserved Domains in DEMETER-Mediated Active DNA Demethylation in planta

This study identifies the functional roles of conserved domains in DEMETER-mediated active DNA demethylation in Arabidopsis, showing that the C-terminal region is sufficient for rescue and the N-terminal region may have regulatory functions.