Cancer cell glycocalyx thickness is a druggable physical phenotype for improving cellular immunotherapy
Sangwoo Park, Justin H. Paek, Marshall J. Colville, Lingting Huang, Audrey P. Struzyk, Sriram Neelamegham, Marcela Valderrama Maus, Matthew J. Paszek
This paper identifies glycocalyx thickness as a targetable physical phenotype and demonstrates that castanospermine reduces it, enhancing CAR-T cell efficacy against gastric cancer.
bioRxiv · Dec 5, 2024 · PreprintBioengineering