Author

Justin H. Paek

Cornell UniversityORCID 0000-0001-8166-8747Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Andy Lash· 2 shared Brian G. RashiD· 2 shared Carlos Castrillo· 2 shared Daphne QuangiD· 2 shared Douglas Flanzer· 2 shared Gaia Skibinski· 2 shared Jordan M. SorokiniD· 2 shared Justin Nicola· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Andy Lash

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Engineering CAR-T cells to remodel the mucin-rich cancer cell glycocalyx

Sangwoo Park, Cassidy Ho, Alexandra N. Wolff, Yueyang Fan, Amanda A. Bouffard, Justin H. Paek, Adele Mucci, Trisha R. Berger, Matthew J. Paszek, Marcela Valderrama Maus

This study engineers CAR-T cells to secrete KLK5, a protease that remodels the mucin-rich glycocalyx, enhancing CAR-T cell function and tumor control in xenograft models.

bioRxiv · Sep 27, 2026 · PreprintBioengineering

Cancer cell glycocalyx thickness is a druggable physical phenotype for improving cellular immunotherapy

Sangwoo Park, Justin H. Paek, Marshall J. Colville, Lingting Huang, Audrey P. Struzyk, Sriram Neelamegham, Marcela Valderrama Maus, Matthew J. Paszek

This paper identifies glycocalyx thickness as a targetable physical phenotype and demonstrates that castanospermine reduces it, enhancing CAR-T cell efficacy against gastric cancer.

bioRxiv · Dec 5, 2024 · PreprintBioengineering

Cell specificity of adeno-associated virus (AAV) serotypes in human cortical organoids

Morgan M. Stanton, Harsh N. Hariani, Jordan M. Sorokin, Patrick M. Taylor, Sara Modan, Brian G. Rash, Sneha B. Rao, Luigi Enriquez, Daphne Quang, Pei-Ken Hsu, Justin H. Paek, Dorah Owango, Carlos Castrillo, Justin Nicola, Pavan Ramkumar, , Gaia Skibinski

The paper assesses AAV serotype transduction efficiency in human cortical organoids, showing cell-specific tropism and donor variability.

bioRxiv · Apr 13, 2023 · PreprintNeuroscience

Optimization and scaling of patient-derived brain organoids uncovers deep phenotypes of disease

Kevan D. Shah, Rishi Bedi, Alex Rogozhnikov, Pavan Ramkumar, Zhixiang Tong, Brian G. Rash, Morgan M. Stanton, Jordan M. Sorokin, Cagsar Apaydin, Anthony Batarse, Julia Bergamaschi, Robert M. Blattner, Spencer Brown, Anthony Bosshardt, Carlos Castrillo, , G. Sean Escola

This paper develops an automated system to scale patient-derived brain organoids, revealing consistent donor and batch effects and demonstrating reproducible disease phenotypes in tuberous sclerosis models.

bioRxiv · Aug 26, 2020 · PreprintNeuroscience