Matthew J. Paszek

This study engineers CAR-T cells to secrete KLK5, a protease that remodels the mucin-rich glycocalyx, enhancing CAR-T cell function and tumor control in xenograft models.

This study compares the ability of collagen type II and I to form synovial fluid films and retain lubricin, revealing differences in their functional roles in joint mechanics.

This study shows that a single delayed injection of recombinant human lubricin improves cartilage repair tissue quality and lubrication in a rabbit osteochondral defect model.

This paper identifies glycocalyx thickness as a targetable physical phenotype and demonstrates that castanospermine reduces it, enhancing CAR-T cell efficacy against gastric cancer.

This paper develops multifunctional reagents for nanoscale imaging of glycans using expansion microscopy, validated in C. elegans and mammalian cells.

The paper shows that dimerization activates the Inversin complex in C. elegans, with optogenetic stimulation and genetic studies supporting this mechanism.

This study develops recombinant lubricin analogs with improved biocompatibility and lubricating properties, demonstrating their tissue binding and joint retention in rats.

This study shows that collagen mineralization increases NK cell resistance in breast cancer by thickening the tumor cell glycocalyx through enhanced sialylation.