Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of k18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2
Gary D. Ewart, Michael D. Bobardt, Bo Hjorth Bentzen, Yannan Yan, Audrey Thomson, Klaus Klumpp, Stephen L. Becker, METTE MARIE ROSENKILDE, Michelle Miller, Philippe A. Gallay
This paper shows that BIT225, an E-protein inhibitor, reduces disease severity and increases survival in SARS-CoV-2 infected mice when administered before or after infection.
PLoS Pathogens · Aug 7, 2023Peer-reviewedMolecular Biology