Safety profiling of CAR-T cells using an organotypic human tissue platform
Alice Machado, Gary Birsen, Irena Rajnpreht, Izadora Peter Furtado, Salut Colell, Berta Marzal, Maxime Fredon, Kai Ziegler-Martin, Darel Martinez Bedoya, Mattia Fumagalli, Lene Vimeux, Suzel Davanture, Fabien Melchiore, Aurélie Thomas, Mélanie Collet, , Emmanuel Donnadieu
This paper develops an organotypic human tissue platform to assess CAR-T cell toxicity and shows it can predict tissue-specific toxicity profiles and identify factors influencing off-tumor effects.
bioRxiv · Jul 28, 2026 · PreprintImmunology