Author

Mattia Fumagalli

Centre National de la Recherche ScientifiqueORCID 0009-0001-1087-8509Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Emmanuel DonnadieuiD· 2 shared Alice MachadoiD· 1 shared Anaïs Vermare· 1 shared Andrea ValentiniiD· 1 shared Audrey Mansuet‐LupoiD· 1 shared Aurélie Thomas· 1 shared Barbara BurroniiD· 1 shared Berta MarzaliD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

Emmanuel DonnadieuORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJul 28, 2026

Safety profiling of CAR-T cells using an organotypic human tissue platform

Alice Machado, Gary Birsen, Irena Rajnpreht…·Emmanuel Donnadieu

This paper develops an organotypic human tissue platform to assess CAR-T cell toxicity and shows it can predict tissue-specific toxicity profiles and identify factors influencing off-tumor effects.

DOI 10.64898/2026.07.25.740527

humanexperimental assay

𝕏 PostBluesky

ImmunologyMolecular TherapyPeer-reviewedApr 4, 2026

An in vivo CRISPR screen unveils top target genes to improve CAR-T cell efficacy in a solid tumor model

Mattia Fumagalli, Dongjie An, Luca Simula…·Frédéric Pendino

This study uses an in vivo CRISPR screen to identify genes that enhance CAR-T cell efficacy in a solid tumor model, finding that disrupting REGNASE-1, SOCS1, PTPN2, and P16/NK4A improves tumor eradication.

4 citationstop 1%

humangenetic perturbation / CRISPR

𝕏 PostBluesky