An approach to characterize mechanisms of action of anti-amyloidogenic compounds in vitro and in situ
Patrick Stalder, T. Serdiuk, Dhiman Ghosh, Yanick Fleischmann, Liliana Malinovska, Aurélien Davranche, Walther Haenseler, Cédric Boudou, Elpida Tsika, A. Ouared, Jan Stöhr, Ronald Melki, Roland Riek, Natalie de Souza, Paola Picotti
This paper introduces a structural proteomic pipeline to study anti-amyloidogenic compounds' mechanisms in vitro and in situ, revealing off-target effects and structural interactions with α-Synuclein.
bioRxiv · Dec 18, 2023 · PreprintSystems Biology