Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies
Tetiana Serdiuk, Virginie Redeker, Jimmy Savistchenko…·Paola Picotti
This study identifies structural and functional differences in alpha-synuclein fibrils from Parkinson's disease, Dementia with Lewy Bodies, and Multiple System Atrophy, linking these differences to disease-specific cellular responses and potential therapeutic targets.