Liliana Malinovska

Deconvolving the structural heterogeneity of alpha-Synuclein in vitro and in situ

This paper develops a method to quantitatively analyze the structural states of alpha-synuclein in vitro and in situ, revealing conformational changes in yeast and human neurons.

A flexible end-to-end automated sample preparation workflow enables reproducible large-scale bottom-up proteomics

This paper develops an automated sample preparation platform for bottom-up proteomics, demonstrating improved reproducibility, throughput, and suitability for drug development.

An approach to characterize mechanisms of action of anti-amyloidogenic compounds in vitro and in situ

This paper introduces a structural proteomic pipeline to study anti-amyloidogenic compounds' mechanisms in vitro and in situ, revealing off-target effects and structural interactions with α-Synuclein.

Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation

The paper shows that metabolic enzymes like glutamine synthetase form filaments at low pH during starvation, leading to inactivation and storage, suggesting a general mechanism for cellular adaptation to starvation.