Split intein vectors permit oversize FLIM-FRET biosensor neuronal expression
Jeong Oen Lee, Henry L. Puhl, Abigail M Holder, Aurora Sheridan, Caleb Darden, Muhammad Shah, William Dunne, Tuan Nguyen, Kirk Hines, Shana M. Augustin, Youngchan Kim, Steven S. Vogel, David M. Lovinger
The paper develops a split intein strategy to deliver oversized FLIM-FRET biosensors for neuronal cAMP monitoring in behaving mice.
bioRxiv · Jun 5, 2026 · PreprintBioengineering