David M. Lovinger

This paper introduces an integrated platform for pose estimation that supports both offline analysis and real-time deployment on edge devices without requiring workstation-grade hardware.

The paper develops a split intein strategy to deliver oversized FLIM-FRET biosensors for neuronal cAMP monitoring in behaving mice.

The paper identifies a circuit mechanism in the globus pallidus externa that regulates risk-taking behavior through specific neuronal activity.

This paper identifies the role of somatostatin interneurons in the motor cortex in refining motor programs through adaptive changes in neural activity patterns during task learning and execution.

This study shows that ADH1-mediated ethanol metabolism affects ethanol consumption and drinking patterns in mice, with Adh1 KO and inhibitor treatments reducing consumption and altering drinking microstructure.

This paper introduces a statistical framework for analyzing trial-level temporal dynamics in fiber photometry experiments, revealing previously obscured effects in dopamine responses to reward.

This study shows that a ketone ester-enriched diet improves motor function and dopamine release in MitoPark mice with Parkinson's disease-like symptoms.

This study shows chronic alcohol enhances synaptic inputs from the dorsolateral striatum to the substantia nigra pars reticulata, increasing their role in action control.

The paper evaluates dLight photometry for measuring dopamine dynamics in the dorsolateral striatum, showing it can detect dopamine increases and transient kinetics during cocaine exposure and conditioning.

This study shows that deleting D2 receptors from striatal cholinergic interneurons impairs action sequence learning, while viral replacement rescues this behavior.

The paper investigates how CB1 and GABAB receptors modulate presynaptic GABA release in striatal indirect pathway projections to the globus pallidus in mice, finding distinct mechanisms for each receptor.

This study examines sex-dependent changes in striatal dopamine release, sleep, and behavior during THC abstinence in mice, finding more consistent effects in males.

This study shows that gestational ethanol exposure in mice causes sex-specific striatal deficits in acetylcholine and dopamine function, linked to impaired motor learning and altered receptor modulation.

This study shows that deficiency in DAGLB, an endocannabinoid synthase, contributes to Parkinson's disease by impairing dopaminergic neuron function and motor learning, with potential therapeutic implications for 2-AG augmentation.

This study investigates the mechanisms of 2-AG mobilization in the dorsal lateral striatum following synaptic stimulation, revealing the roles of glutamatergic and cholinergic neurotransmission.

The paper introduces a genetically encoded fluorescent sensor, GRABeCB2.0, to measure endocannabinoid dynamics with high spatiotemporal resolution in vitro and in vivo, revealing new insights into eCB signaling in neurons and brain regions.

This study examines how binge drinking affects globus pallidus connectivity and its relationship with impulsivity and drinking behaviors in humans.

The paper shows that optogenetic stimulation of thalamic terminals in the dorsomedial striatum reinforces operant behavior, and that mGlu2 activation limits this reinforcement.