Multiomics-driven discovery of predictive biomarkers and strategies to overcome resistance to SFK-YAP inhibition in cholangiocarcinoma
Hendrien Kuipers, Danielle Marie Carlson, Erik Jessen, Aushinie M. Abeynayake, Jack W. Sample, Dong‐Gi Mun, Jennifer L. Tomlinson, Amro M. Abdelrahman, Nathan W. Werneburg, Binbin Li, Enis H. Ozmert, Caitlin B. Conboy, Mitesh J. Borad, Mark Joseph Truty, Akhilesh Pandey, , Rory L. Smoot
This study identifies biomarkers and resistance mechanisms to SFK-YAP inhibition in cholangiocarcinoma using multiomic profiling and shows synergy with chemotherapy.
bioRxiv · Jan 23, 2026 · PreprintCancer Biology