PNPLA3I148M is a novel regulator of bone mass independent of MASLD
Galen Goldscheitter, Mulugeta Seneshaw, Faridoddin Mirshahi, Morgan Summerlin, Allison Ip, Austin Coelho, Ronnie Li, Damian C. Genetos, Arun Jayant Sanyal, Henry J. Donahue
The paper investigates the effect of PNPLA3I148M on bone mass in a mouse model, finding it causes bone loss and alters bone metabolism independently of MASLD.
bioRxiv · Mar 17, 2026 · PreprintPhysiology