Arun Jayant Sanyal

This study identifies RUNX1 as a key transcriptional regulator of fibrogenic and inflammatory signaling in cholangiocytes, showing its inhibition reduces biliary fibrosis and inflammation in models of cholangiopathy.

The paper investigates the effect of PNPLA3I148M on bone mass in a mouse model, finding it causes bone loss and alters bone metabolism independently of MASLD.

This study shows Aramchol reduces fibrosis in mouse models of biliary disease by inhibiting TGFβ-induced inflammation and fibrotic markers in cholangiocytes.

This study investigates sex differences in bone loss associated with MASLD using DIAMOND mice, identifying potential liver-secreted factors involved in bone resorption.

The paper shows that anti-tumor immunity in HCC relies on monocyte-driven tissue homeostasis rather than direct tumor cytotoxicity, highlighting the importance of restoring liver integrity.

The paper analyzes isomiR expression in MASLD liver biopsies and identifies isomiRs associated with disease severity and fibrosis, proposing novel mRNA targets.

This study conducts a trans-ancestry GWAS using chronic ALT elevation as a proxy for NAFLD, identifies 77 significant loci, and validates 17 SNPs with histology and imaging data, revealing genetic links to metabolic and inflammatory traits.