Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers
Jun Tang, Natasha E. Weiser, Guiping Wang, Sudhir Chowdhry, Ellis J. Curtis, Yanding Zhao, Ivy Tsz-Lo Wong, Georgi K. Marinov, Rui Li, Philip Hanoian, Edison Tse, Salvador Garcia Mojica, Ryan J. Hansen, Joshua Plum, Auzon Steffy, , Howard Y. Chang
This paper identifies transcription-replication conflict as a vulnerability in ecDNA-containing cancers and demonstrates that CHK1 inhibition selectively kills these tumors.
Nature · Nov 6, 2024Peer-reviewedCancer Biology