Yanding Zhao

ecDNAInspector identifies high-confidence ecDNA structures from WGS data, linking them to clinical and molecular features in breast cancer.

The paper shows that ecDNA-borne PVT1 fusions stabilize oncogenic mRNAs by interacting with SRSF1, enhancing RNA stability and supporting MYC dependency in cancer.

The paper identifies autoantibody hotspots on the XIST RNP complex in female-biased autoimmune diseases and links them to clinical outcomes.

This paper identifies transcription-replication conflict as a vulnerability in ecDNA-containing cancers and demonstrates that CHK1 inhibition selectively kills these tumors.

This study shows that Xist ribonucleoprotein complexes drive sex-biased autoimmunity in males, leading to autoimmune pathology and reprogramming of immune cells to resemble female patterns.