Mast cell extracellular granules are bioactive condensates driven by heparin and polyamine
Yiwei Xiong, Dylan T. Tomares, JianJian Guo, K. Satoh, Longhui Zeng, Yuan Tian, Maohan Su, Ava Albis, Avnika Pant, Rohit V. Pappu, Xiaolei Su
This study identifies mast cell extracellular granules as bioactive condensates formed by heparin and polyamines, enhancing enzymatic activity and cytokine bioactivity.
bioRxiv · Dec 26, 2025 · PreprintCell Biology