Yuan Tian

SPC-Clean reduces speckle and isolated pixel noise in fluorescence microscopy images using a topology-aware method without altering fluorescence intensities.

This study identifies mast cell extracellular granules as bioactive condensates formed by heparin and polyamines, enhancing enzymatic activity and cytokine bioactivity.

This paper shows that renalase activates mitochondrial leak metabolism to enhance protein synthesis and protect cells from stress and injury.

The paper introduces pan-ASLM, a light sheet microscope optimized for expansion microscopy, achieving higher speed, larger field of view, and better resolution than standard confocal microscopes.

This paper introduces MAPS, a deep-learning approach for automated segmentation of mitochondrial ultrastructure in 3D pan-ExM images, enabling high-throughput quantification of morphology and protein localization.

The paper uses super-resolution microscopy to show golgin proteins form a tetraplex at the Golgi rim and self-assemble into filamentous bands, proposing a model for Golgi stack formation.