Glycomics Profiling Reveals a Stromal Chondroitin-4-sulfate State that Shapes Platinum Response in Ovarian Cancer
Erica J. Peterson, James D. Hampton, Thomas Mandel Clausen, Ava RS Beaudin, Sharanya Deshmukh, Mikhail G. Dozmorov, Joseph B. McGee Turner, Amrita Basu, Elena Ethel Vidal-Calvo, Corinne E. Leonard, Priscilla Y. Hwang, Mads Daugaard, Ali Salanti, Ryan J. Weiss, Jennifer E. Koblinski, , Nicholas P. Farrell
This study identifies stromal chondroitin-4-sulfate as a determinant of platinum response in ovarian cancer through glycomics profiling and functional validation.
bioRxiv · Oct 6, 2025 · PreprintCancer Biology