Jennifer E. Koblinski

This study identifies an EZH2/TRIM28 epigenetic axis that regulates heparan sulfate remodeling and promotes melanoma metastasis.

This study shows that combining sacituzumab govitecan with the senolytic ABT-263 effectively overcomes chemoresistance in HNSCC by targeting senescent cells.

This study shows that Daraxonrasib (RMC-6236) effectively targets RAS-mutant neuroblastoma by inhibiting MAPK signaling and enhancing cell death.

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

This study identifies stromal chondroitin-4-sulfate as a determinant of platinum response in ovarian cancer through glycomics profiling and functional validation.

This study evaluates the safety, pharmacokinetics, and neuroprotective effects of intramuscular verapamil in a rat model of organophosphate-induced status epilepticus, showing improved brain levels and neuroprotection compared to oral administration.

This study shows proteasome inhibitors are more effective against NSCLC cells with mutant p53 by inducing oxidative stress and mitochondrial apoptosis, suggesting a new therapeutic strategy.