Ryan J. Weiss

This study shows that lysosomal glycosaminoglycan catabolism in microglia regulates their cell state during CNS development, linking ECM remodeling to microglial identity.

This study identifies an EZH2/TRIM28 epigenetic axis that regulates heparan sulfate remodeling and promotes melanoma metastasis.

The paper uses CRISPR activation screens to identify proteoglycan core proteins, particularly SDC1, as key regulators of heparan sulfate sulfation and ligand specificity.

This study identifies sumf2 as a key regulator of convergence and extension morphogenesis timing in zebrafish by modulating sulfatase activity and heparan sulfate sulfation.

This study shows that mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation through interactions with heparan sulfate proteoglycans.

This study identifies stromal chondroitin-4-sulfate as a determinant of platinum response in ovarian cancer through glycomics profiling and functional validation.

This study identifies glycosaminoglycan-mediated lipoprotein uptake as a mechanism by which cancer cells resist ferroptosis and lipid oxidative stress.

The paper investigates how heparan sulfate-modified proteoglycans influence AD-related pathways by modulating presenilin function in human cells, mouse astrocytes, and Drosophila.

PinAPL-Py provides a user-friendly web application for analyzing CRISPR/Cas9 screening data, offering comprehensive tools and workflows for sequence analysis and gene ranking.