Amrita Basu

Lysosomal Glycosaminoglycan Catabolism Regulates Microglial Cell State in the Developing CNS

This study shows that lysosomal glycosaminoglycan catabolism in microglia regulates their cell state during CNS development, linking ECM remodeling to microglial identity.

A non-canonical EZH2/TRIM28 epigenetic axis drives heparan sulfate remodeling and melanoma metastasis

This study identifies an EZH2/TRIM28 epigenetic axis that regulates heparan sulfate remodeling and promotes melanoma metastasis.

CRISPR activation screens identify core protein-dependent regulation of heparan sulfate sulfation and ligand specificity

The paper uses CRISPR activation screens to identify proteoglycan core proteins, particularly SDC1, as key regulators of heparan sulfate sulfation and ligand specificity.

Sulfatase modifying factors control the timing of zebrafish convergence and extension morphogenesis

This study identifies sumf2 as a key regulator of convergence and extension morphogenesis timing in zebrafish by modulating sulfatase activity and heparan sulfate sulfation.

Mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation

This study shows that mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation through interactions with heparan sulfate proteoglycans.

Glycomics Profiling Reveals a Stromal Chondroitin-4-sulfate State that Shapes Platinum Response in Ovarian Cancer

This study identifies stromal chondroitin-4-sulfate as a determinant of platinum response in ovarian cancer through glycomics profiling and functional validation.

Glycosaminoglycan-mediated lipoprotein uptake protects cancer cells from ferroptosis

This study identifies glycosaminoglycan-mediated lipoprotein uptake as a mechanism by which cancer cells resist ferroptosis and lipid oxidative stress.