Lipid metabolic perturbation is an early-onset phenotype in adult spin mutants: a Drosophila model for lysosomal storage disorders
sarita hebbar, Avinash Khandelwal, Jayashree R, Samantha J Hindle, Yin Ning Chiang, Joanne Yew, Sean Sweeney, Dominik Schwudke
This study identifies lipid metabolic imbalances in Drosophila spin mutants, linking ceramide/sphingosine homeostasis to early neurodegeneration in lysosomal storage disorders.
bioRxiv · Sep 16, 2016Cell Biology