Sarita Hebbar

This study shows that mutations in the splicing factor Prp31 in Drosophila cause light-dependent retinal degeneration by increasing rhodopsin 1 accumulation, which can be mitigated by reducing rhodopsin levels.

This study uses a Drosophila model to investigate the effects of Prp31 mutations, showing light-induced retinal degeneration linked to oxidative stress and splicing defects.

This paper characterizes a Drosophila model of saposin deficiency, showing lysosomal storage, neurodegeneration, and calcium homeostasis defects similar to human LSDs.

This study identifies lipid metabolic imbalances in Drosophila spin mutants, linking ceramide/sphingosine homeostasis to early neurodegeneration in lysosomal storage disorders.