Dominik Schwudke

Intracellular compartmentalization shapes lipid access and metabolic fitness of mycobacteria

The paper shows that lipid metabolism in mycobacteria is linked to their subcellular location, with FACL6 deletion disrupting lipid handling and reducing intracellular fitness.

Lipidome visualisation, comparison, and analysis in a vector space

The paper uses a shallow neural network to embed lipid structures in a vector space for structural analysis and visualization, with a web tool for exploratory lipidomics data analysis.

A Saposin deficiency model in Drosophila: lysosomal storage, progressive neurodegeneration, sensory physiological decline and defective calcium homeostasis

This paper characterizes a Drosophila model of saposin deficiency, showing lysosomal storage, neurodegeneration, and calcium homeostasis defects similar to human LSDs.

Lipid metabolic perturbation is an early-onset phenotype in adult spin mutants: a Drosophila model for lysosomal storage disorders

This study identifies lipid metabolic imbalances in Drosophila spin mutants, linking ceramide/sphingosine homeostasis to early neurodegeneration in lysosomal storage disorders.