RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and initiates a novel mRNA decay pathway
Shiladitya Chattopadhyay, José García‐Martínez, Gal Haimovich, Jonathan D. Fischer, Aya Khwaja, Oren Barkai, Silvia Gabriela Chuartzman, Maya Schuldiner, Ron Elran, Miriam I. Rosenberg, Shira Urim, Shubham Deshmukh, Katherine E. Bohnsack, Markus T. Bohnsack, José Enrique Pérez-Ortín, Mordechai Choder
The paper shows that RNA-controlled shuttling of Xrn1 and its decay factors regulates mRNA synthesis and decay, revealing a novel nuclear-initiated cytoplasmic decay pathway.
Nature Communications · Nov 23, 2022Peer-reviewedMolecular Biology