Gal Haimovich

The paper identifies the syntax of SECReTE, a secretion-enhancing cis regulatory element, through a parallel reporter screen in mammalian cells, revealing key sequence patterns and their impact on mRNA localization and protein secretion.

This study shows that intercellular mRNA transfer via tunneling nanotubes can complement genetic mutations in vitro, as demonstrated by peroxisome biogenesis in Zellweger Syndrome models.

The paper shows that RNA-controlled shuttling of Xrn1 and its decay factors regulates mRNA synthesis and decay, revealing a novel nuclear-initiated cytoplasmic decay pathway.

The paper identifies SECReTE cis-acting RNA motifs in SARS-CoV-2 and other (+)ssRNA viruses, showing their association with ER-related functions and potential as drug targets.