Aryl-hydrocarbon receptor in smooth muscle cells protect against dioxin induced adverse remodeling of atherosclerosis
Guyu Tracy Qin, Quanyi Zhao, Ayaka Fujita, Isabella Damiani, Meena Easwaran, Sugandha Basu, Wenduo Gu, Daniel Yuhang Li, Matthew D. Worssam, Brian T. Palmisano, João P. Monteiro, Markus O Ramste, Ramendra Krishna Kundu, Trieu Nguyen, Chong Yon Park, , Juyong Brian Kim
This study shows dioxin exposure accelerates atherosclerosis by promoting inflammatory smooth muscle cell phenotypes and oxidative stress, with AHR in SMC providing protective effects.
bioRxiv · Sep 24, 2024 · PreprintMolecular Biology