Brian T. Palmisano

An in vitro System for Studying Osteochondrogenic Differentiation of Smooth Muscle Cells and Modeling Intimal Vascular Calcification

This paper develops an in vitro system that mimics osteochondrogenic differentiation of smooth muscle cells and intimal vascular calcification, showing distinct transcriptional states compared to standard calcification assays.

Vascular smooth muscle cell atherosclerosis trajectories characterized at single cell resolution identify causal transcriptomic and epigenomic mechanisms of disease risk

The paper characterizes atherosclerosis trajectories in vascular smooth muscle cells using single-cell data and identifies causal transcriptomic and epigenomic mechanisms of CAD risk.

A cell and transcriptome atlas of human arterial vasculature

This study creates a transcriptomic and spatial atlas of human arterial segments, revealing cell-type and segment-specific heterogeneity linked to vascular disease risk.

Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of RNA sensor MDA5 in atherosclerosis

The paper links ADAR1-mediated RNA editing in smooth muscle cells to regulation of MDA5 activation, showing its role in atherosclerosis progression and vascular calcification.

Aryl-hydrocarbon receptor in smooth muscle cells protect against dioxin induced adverse remodeling of atherosclerosis

This study shows dioxin exposure accelerates atherosclerosis by promoting inflammatory smooth muscle cell phenotypes and oxidative stress, with AHR in SMC providing protective effects.

The epigenomic landscape of single vascular cells reflects developmental origin and identifies disease risk loci

The paper identifies vascular site-specific epigenomic and transcriptomic features and links them to disease risk loci using single-cell data and GWAS integration.