Tight junction component protein claudin-1 deficiency in retinal pigment epithelium leads to early and intermediate age-related macular degeneration phenotypes in mice.
Ayaka Nakai, Deokho Lee, Yan Zhang, Chiho Shoda, Tetsu Imanishi, Heonuk Jeong, Shin‐ichi Ikeda, Kazuno Negishi, Hiroyuki Nakashizuka, Satoru Yamagami, Akiharu Kubo, Toshihide Kurihara
This study shows that claudin-1 deficiency in mouse retinal pigment epithelium leads to AMD-like phenotypes including drusenoid deposits and pigment abnormalities.
bioRxiv · Dec 7, 2023 · PreprintMolecular Biology